Products

NumeriCor offers a suite of cardiac, multi-physics, simulation tools. The main components are the simulation engine CARP-EP, the end-to-end graphical front-end Studio, and the cardiac model generation tool CardioTwin.

Cardiac Electrophysiology Simulation

A brief overview of the cardiac electrophysiology simulation workflow

In cardiac electrophysiology simulations, we predict organ response to therapy on cohorts of virtual twins, which are generated based on clinical MRI or CT scans.

The scan images are segmented and converted into three-dimensional volumetric geometries, which are then enriched with rule-based fiber and anatomy data. This process can be performed either interactively using NumeriCor Studio, or automatically using the our automated pipeline CardioTwin. Electrophysiological properties, such as cellular dynamics and tissue conductivities, are assigned to the different anatomical regions of the heart using NumeriCor Studio. Once completed, the virtual twins can be used for therapy outcome prediction.

NumeriCor Studio

Interactive high-performance
pre- and post-processing

Studio is an end-to-end graphical simulation front-end designed custom-tailored to CARPentry electrophysiology simulations. It highly optimized and includes all workflows required for cardiac simulations.

Studio allows the user to visualize and automatically segment clinical images, generate model geometries, prepare in-silico experiments, and analyze simulation results, all in the same tool.

CARPentry Studio Device integration

Device integration

Rule-based or CAD-based device designs are efficiently integrated into virtual twins.

CARPentry Studio Device integration

Functionalization

Generate rule-based fibers and anatomical region annotations.

CARPentry Studio Device integration

Purkinje generation

Generate Purkinje cardiac conduction systems interactively or rule-based within seconds.

CARPentry Studio Device integration

Automated Segmentation

Generate automatically 7-label segmentations from clinical CT or MRI data-sets.

NumeriCor CARP-EP

High-fidelity multi-scale cardiac simulation engine

CARP-EP, formerly CARPentry Pro, is the commercial implementation of the multiscale-multiphysics cardiac simulation software CARPentry and its predecessor CARP. It models cardiac electrophysiology, mechanics and hemodynamics at cellular, tissue and organ scales with unmatched fidelity and performance. CARP-EP and its academic predecessors have been used in > 250 peer-reviewed journal publications. It is used by leading academic labs in Europe and the US, with a base of >100 users worldwide.

NumeriCor CardioTwin

AUtomated cardiac model generation

CardioTwin is an automated tool for generating highly detailed bi-atrial, bi-ventricular and full heart models from clinical imaging data in <5 minutes. The resulting models are fully parametrized and ready for electrophysiology simulations.

Optionally, CardioTwin can integrate Studio for automated image segmentation, workflow supervision and refinement.

CARPentry Studio Device integration

Robust against variability

CardioTwin has been tested on hundreds of clinical CT and MRI datasets to ensure robustness with respect to variability in patient physiology.

CARPentry Studio Device integration

Fully parametrized

The generated models are fully parametrized, including rule-based fiber orientations, rule-based atrial region annotation, and reference frames.

CARPentry Studio Device integration

Virtual cohorts & personalized therapy

Create virtual cohorts to conduct in-silico clinical trials or build digital replicas of your patients to test new devices and treatments.