Products
NumeriCor offers a suite of cardiac, multi-physics, simulation tools. The main components are the simulation engine CARP-EP, the end-to-end graphical front-end Studio, and the cardiac model generation tool CardioTwin.
Cardiac Electrophysiology Simulation
A brief overview of the cardiac electrophysiology simulation workflow
In cardiac electrophysiology simulations, we predict organ response to therapy on cohorts of virtual twins, which are generated based on clinical MRI or CT scans.
The scan images are segmented and converted into three-dimensional volumetric geometries, which are then enriched with rule-based fiber and anatomy data. This process can be performed either interactively using NumeriCor Studio, or automatically using the our automated pipeline CardioTwin. Electrophysiological properties, such as cellular dynamics and tissue conductivities, are assigned to the different anatomical regions of the heart using NumeriCor Studio. Once completed, the virtual twins can be used for therapy outcome prediction.
NumeriCor Studio
Interactive high-performance
pre- and post-processing
Studio is an end-to-end graphical simulation front-end designed custom-tailored to CARPentry electrophysiology simulations. It highly optimized and includes all workflows required for cardiac simulations.
Studio allows the user to visualize and automatically segment clinical images, generate model geometries, prepare in-silico experiments, and analyze simulation results, all in the same tool.
Device integration
Rule-based or CAD-based device designs are efficiently integrated into virtual twins.
Functionalization
Generate rule-based fibers and anatomical region annotations.
Purkinje generation
Generate Purkinje cardiac conduction systems interactively or rule-based within seconds.
Automated Segmentation
Generate automatically 7-label segmentations from clinical CT or MRI data-sets.
NumeriCor CARP-EP
High-fidelity multi-scale cardiac simulation engine
CARP-EP, formerly CARPentry Pro, is the commercial implementation of the multiscale-multiphysics cardiac simulation software CARPentry and its predecessor CARP. It models cardiac electrophysiology, mechanics and hemodynamics at cellular, tissue and organ scales with unmatched fidelity and performance. CARP-EP and its academic predecessors have been used in > 250 peer-reviewed journal publications. It is used by leading academic labs in Europe and the US, with a base of >100 users worldwide.
NumeriCor CardioTwin
AUtomated cardiac model generation
CardioTwin is an automated tool for generating highly detailed bi-atrial, bi-ventricular and full heart models from clinical imaging data in <5 minutes. The resulting models are fully parametrized and ready for electrophysiology simulations.
Optionally, CardioTwin can integrate Studio for automated image segmentation, workflow supervision and refinement.
Robust against variability
CardioTwin has been tested on hundreds of clinical CT and MRI datasets to ensure robustness with respect to variability in patient physiology.
Fully parametrized
The generated models are fully parametrized, including rule-based fiber orientations, rule-based atrial region annotation, and reference frames.
Virtual cohorts & personalized therapy
Create virtual cohorts to conduct in-silico clinical trials or build digital replicas of your patients to test new devices and treatments.